Is there any problems with running e85 ethanol?

Is there any problems with running e85 ethanol?
There should not be, IF your vehicle is set up to use it, typically identified by a "Flex Fuel" nameplate somewhere on the car or truck. One advantage of E85 is reduced contamination in the lubricant (engine oil), since alcohol burns with considerably fewer byproducts than gasoline. The biggest drawback is reduced fuel economy, which can vary a bit between vehicles, but is pretty much universal. E85 simply contains less energy per gallon than gasoline. It therefore requires more E85 to drive the same distance, as compared with gas. Whether or not it makes economic sense to use E85 is up to individual drivers.

If your car or truck was made before about 2006, it is very unlikely that it can use anything other than gasoline. Putting E85 into a vehicle designed to run only on gasoline will cause very many problems, and can even severely damage the fuel system.